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KMID : 0366220060410040311
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Korean Journal of Hematology
2006 Volume.41 No. 4 p.311 ~ p.316
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A Case of Chronic Active Epstein-Barr Virus Infection with Autoimmnune Hepatitis and a Coronary Aneurysm
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Kim Mi-Jin
Lee Ji-Joung
Park Kyoung-Soo
Kim Sun-Young
Kil Hong-Ryang
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Abstract
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Infectious mononucleosis caused by primary infection of Epstein-Barr virus (EBV) is a self-limiting lymphoproliferative disease, and shows concomitant clinical features such as pyrexia, anorexia, sore throat, cervical lymphadenopathy, liver dysfunction and hepatosplenomegaly. In rare cases, EBV establishes a latent infection in B lymphocytes and runs a chronic course and shows infectious mononucleosis-like symptoms repeatedly. This syndrome, named chronic active EBV infection, may trigger an autoimmune disease that mainly affectes the liver and red blood cells, and carries a very poor prognosis. The cardiovascular complications of chronic active EBV infection are very rare and may be associated with coronary arterial disease. This case describes a 5-year-old boy, who developed chronic active EBV infection and was diagnosed as having autoimmune hepatitis with a coronary aneurysm.
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KEYWORD
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Chronic active EBV infection, Autoimmune hepatitis, Coronary aneurysm
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